Pub. Date : 2004 Oct 15
PMID : 15492272
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We now document that overexpression of hPNPase(old-35) results in increased production of ROS, leading to activation of the nuclear factor (NF)-kappaB pathway. | Reactive Oxygen Species | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 2 | The generation of ROS and activation of NF-kappaB by hPNPase(old-35) are prevented by treatment with a cell-permeable antioxidant, N-acetyl-l-cysteine. | Reactive Oxygen Species | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 3 | The generation of ROS and activation of NF-kappaB by hPNPase(old-35) are prevented by treatment with a cell-permeable antioxidant, N-acetyl-l-cysteine. | Acetylcysteine | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 4 | Infection with Ad.hPNPase(old-35) enhances the production of interleukin (IL)-6 and IL-8, two classical NF-kappaB-responsive cytokines, and this induction is inhibited by N-acetyl-l-cysteine. | Acetylcysteine | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 5 | We hypothesize that hPNPase(old-35) might play a significant role in producing pathological changes associated with aging by generating proinflammatory cytokines via ROS and NF-kappaB. | Reactive Oxygen Species | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |