Title : Induced synthesis of O6-methylguanine-DNA methyltransferase in rat hepatoma cells exposed to DNA-damaging agents.

Pub. Date : 1992 Jan

PMID : 1544875






1 Functional Relationships(s)
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1 When the rat hepatoma cell line H4IIE was treated with DNA-damaging agents such as N-methyl-N"-nitro-N-nitrosoguanidine (MNNG), ultraviolet light and gamma-rays, the O6-methylguanine-DNA methyltransferase activity increased 2 to 3 times over the level seen in non-treated cells. Methylnitronitrosoguanidine O-6-methylguanine-DNA methyltransferase Rattus norvegicus