Title : Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism.

Pub. Date : 1992 Feb 15

PMID : 1540140






4 Functional Relationships(s)
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1 Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism. Sphingosine LOC100009319 Oryctolagus cuniculus
2 Furthermore, the hydrolytic action of exogenously added phospholipase C (from Clostridium perfringens) on platelet membrane phospholipids was dose-dependently enhanced by pretreatment of the platelets with sphingosine. Phospholipids LOC100009319 Oryctolagus cuniculus
3 Furthermore, the hydrolytic action of exogenously added phospholipase C (from Clostridium perfringens) on platelet membrane phospholipids was dose-dependently enhanced by pretreatment of the platelets with sphingosine. Sphingosine LOC100009319 Oryctolagus cuniculus
4 These results imply that sphingosine, at relatively low concentrations, brings about hyperaggregability of the platelets by the agonists employed, probably owing to enhancement of the phospholipase C activity. Sphingosine LOC100009319 Oryctolagus cuniculus