Title : Polyamine depletion inhibits etoposide-induced NF-kappaB activation in transformed mouse fibroblasts.

Pub. Date : 2004 Oct

PMID : 15378410






2 Functional Relationships(s)
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1 A two days pre-treatment of fibroblasts with alpha-difluoromethylornithine (DFMO), which caused polyamine depletion, provoked a slight activating effect when given alone, but markedly inhibited the etoposide-induced increases in p65 DNA binding and phosphorylation. Eflornithine v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
2 A two days pre-treatment of fibroblasts with alpha-difluoromethylornithine (DFMO), which caused polyamine depletion, provoked a slight activating effect when given alone, but markedly inhibited the etoposide-induced increases in p65 DNA binding and phosphorylation. Eflornithine v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus