Title : CD157 is an important mediator of neutrophil adhesion and migration.

Pub. Date : 2004 Dec 15

PMID : 15328157






7 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CD157, a glycosylphosphatidylinositol (GPI)-anchored protein encoded by a member of the CD38 NADase/ADP-ribosyl cyclase gene family, is expressed on the surface of most human circulating neutrophils. Glycosylphosphatidylinositols bone marrow stromal cell antigen 1 Homo sapiens
2 CD157, a glycosylphosphatidylinositol (GPI)-anchored protein encoded by a member of the CD38 NADase/ADP-ribosyl cyclase gene family, is expressed on the surface of most human circulating neutrophils. Glycosylphosphatidylinositols bone marrow stromal cell antigen 1 Homo sapiens
3 These signals are independent of the products of CD157"s enzymatic activities (ie, cyclic adenosine diphosphate [ADP]-ribose and ADP-ribose). cyclic adenosine diphosphate bone marrow stromal cell antigen 1 Homo sapiens
4 Indeed, the enzymatic activities of CD157 in circulating neutrophils as well as in dimethyl sulfoxide (DMSO)-differentiated (CD157(+)/CD38(-)) HL-60 cells, are hardly detectable. Dimethyl Sulfoxide bone marrow stromal cell antigen 1 Homo sapiens
5 Indeed, the enzymatic activities of CD157 in circulating neutrophils as well as in dimethyl sulfoxide (DMSO)-differentiated (CD157(+)/CD38(-)) HL-60 cells, are hardly detectable. Dimethyl Sulfoxide bone marrow stromal cell antigen 1 Homo sapiens
6 Indeed, the enzymatic activities of CD157 in circulating neutrophils as well as in dimethyl sulfoxide (DMSO)-differentiated (CD157(+)/CD38(-)) HL-60 cells, are hardly detectable. Dimethyl Sulfoxide bone marrow stromal cell antigen 1 Homo sapiens
7 CD157 localizes in GM1-enriched lipid rafts and, upon activation, it migrates to the uropod, a structure specialized in motility and adhesive functions. G(M1) Ganglioside bone marrow stromal cell antigen 1 Homo sapiens