Title : Fibronectin fragments elevate nitric oxide (NO) and inducible NO synthetase (iNOS) levels in bovine cartilage and iNOS inhibitors block fibronectin fragment mediated damage and promote repair.

Pub. Date : 2004 Aug

PMID : 15316672






2 Functional Relationships(s)
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1 OBJECTIVE AND DESIGN: To determine whether fibronectin fragments (Fn-f) upregulate nitric oxide (NO) and inducible NO synthetase (iNOS) levels in explants and whether iNOS inhibitors block Fn-f mediated cartilage damage or promote repair. fn-f nitric oxide synthase 2 Bos taurus
2 Three different iNOS inhibitors blocked Fn-f mediated PG depletion from explants and facilitated restoration of PG in pre-damaged cartilage. fn-f nitric oxide synthase 2 Bos taurus