Pub. Date : 2004 Sep 10
PMID : 15302583
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Signal transduction pathway and a new function of TIS21/BTG2/PC3 were investigated in p53 null U937 cells; Expression of TIS21 by 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation was mediated by PKC-delta activation, however, was strongly inhibited by cPKC isozymes. | Tetradecanoylphorbol Acetate | BTG anti-proliferation factor 2 | Homo sapiens |
| 2 | Signal transduction pathway and a new function of TIS21/BTG2/PC3 were investigated in p53 null U937 cells; Expression of TIS21 by 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation was mediated by PKC-delta activation, however, was strongly inhibited by cPKC isozymes. | Tetradecanoylphorbol Acetate | BTG anti-proliferation factor 2 | Homo sapiens |
| 3 | Signal transduction pathway and a new function of TIS21/BTG2/PC3 were investigated in p53 null U937 cells; Expression of TIS21 by 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation was mediated by PKC-delta activation, however, was strongly inhibited by cPKC isozymes. | Tetradecanoylphorbol Acetate | BTG anti-proliferation factor 2 | Homo sapiens |
| 4 | Signal transduction pathway and a new function of TIS21/BTG2/PC3 were investigated in p53 null U937 cells; Expression of TIS21 by 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation was mediated by PKC-delta activation, however, was strongly inhibited by cPKC isozymes. | Tetradecanoylphorbol Acetate | BTG anti-proliferation factor 2 | Homo sapiens |
| 5 | When U937 cells were treated with TPA+Go6976, but not TPA+Go6850, the level of TIS21 mRNA was maintained over that of TPA alone. | Tetradecanoylphorbol Acetate | BTG anti-proliferation factor 2 | Homo sapiens |
| 6 | When U937 cells were treated with TPA+Go6976, but not TPA+Go6850, the level of TIS21 mRNA was maintained over that of TPA alone. | Go 6976 | BTG anti-proliferation factor 2 | Homo sapiens |
| 7 | When analyzed by FACS, TPA-induced G2/M arrest was significantly inhibited by Go6850, but not by Go6976, suggesting the involvement of TIS21 and nPKC isozymes. | Tetradecanoylphorbol Acetate | BTG anti-proliferation factor 2 | Homo sapiens |
| 8 | When the cells were synchronized by nocodazole, TIS21 overexpressers inhibited degradations of cyclin A and cyclin B1 in 3 h after release from the synchronization. | Nocodazole | BTG anti-proliferation factor 2 | Homo sapiens |
| 9 | In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2. | Tetradecanoylphorbol Acetate | BTG anti-proliferation factor 2 | Homo sapiens |