Title : Rapamycin-mediated induction of gamma-globin mRNA accumulation in human erythroid cells.

Pub. Date : 2004 Aug

PMID : 15287957






3 Functional Relationships(s)
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1 The results suggested that rapamycin, when compared with cytosine arabinoside, mithramycin and cisplatin, is a powerful inducer of erythroid differentiation and gamma-globin mRNA accumulation in human leukaemia K562 cells. Sirolimus hemoglobin subunit gamma 1 Homo sapiens
2 The results suggested that rapamycin, when compared with cytosine arabinoside, mithramycin and cisplatin, is a powerful inducer of erythroid differentiation and gamma-globin mRNA accumulation in human leukaemia K562 cells. Cisplatin hemoglobin subunit gamma 1 Homo sapiens
3 In addition, when normal human erythroid precursors were cultured in the presence of rapamycin, gamma-globin mRNA accumulation and fetal haemoglobin (HbF) production increased to levels that were higher than those obtained using hydroxyurea. Sirolimus hemoglobin subunit gamma 1 Homo sapiens