Title : The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules.

Pub. Date : 2004 Aug

PMID : 15284287






4 Functional Relationships(s)
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1 Vectorial transport of 2,4-dichlorophenoxyacetate was observed in the basal-to-apical direction in rat organic anion transporter 3-expressing LLC-PK1 cells (rOat3-LLC); however, coexpression of mouse RST in rOat3-LLC caused a 1.3-fold increase in the basal-to-apical transport. 2,4-Dichlorophenoxyacetic Acid solute carrier family 22 member 8 Rattus norvegicus
2 Vectorial transport of 2,4-dichlorophenoxyacetate was observed in the basal-to-apical direction in rat organic anion transporter 3-expressing LLC-PK1 cells (rOat3-LLC); however, coexpression of mouse RST in rOat3-LLC caused a 1.3-fold increase in the basal-to-apical transport. 2,4-Dichlorophenoxyacetic Acid solute carrier family 22 member 8 Rattus norvegicus
3 In addition, the basal-to-apical transport of benzylpenicillin and urate was 3- and 2.5-fold greater than that in the opposite direction in the double-transfected cells, respectively, whereas their transepithelial transport in vector- or rOat3-LLC was symmetrical. Penicillin G solute carrier family 22 member 8 Rattus norvegicus
4 In addition, the basal-to-apical transport of benzylpenicillin and urate was 3- and 2.5-fold greater than that in the opposite direction in the double-transfected cells, respectively, whereas their transepithelial transport in vector- or rOat3-LLC was symmetrical. Uric Acid solute carrier family 22 member 8 Rattus norvegicus