Pub. Date : 2004 Aug 20
PMID : 15199053
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. | 15-deoxy-delta(12,14)-prostaglandin J2 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 2 | We have previously shown that non-pathogenic Gram-negative Bacteroides vulgatus induces transient RelA phosphorylation (Ser-536), NF-kappaB activity, and pro-inflammatory gene expression in native and intestinal epithelial cell (IEC) lines. | Serine | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 3 | We now demonstrate that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) but not prostaglandin E(2) inhibits lipopolysaccharide (LPS) (B. vulgatus)/LPS (Escherichia coli)-induced RelA phosphorylation and interleukin-6 gene expression in the colonic epithelial cell line CMT-93. | 15-deoxy-delta(12,14)-prostaglandin j | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 4 | In addition, 15d-PGJ(2) but not the synthetic high affinity PPARgamma ligand rosiglitazone triggered ERK1/2 phosphorylation in IEC, and most importantly, MEK1 inhibitor PD98059 reversed the inhibitory effect of 15dPGJ(2) on LPS-induced RelA phosphorylation and interleukin-6 gene expression. | 15d-pgj | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 5 | In addition, 15d-PGJ(2) but not the synthetic high affinity PPARgamma ligand rosiglitazone triggered ERK1/2 phosphorylation in IEC, and most importantly, MEK1 inhibitor PD98059 reversed the inhibitory effect of 15dPGJ(2) on LPS-induced RelA phosphorylation and interleukin-6 gene expression. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 6 | Calyculin A, a specific phosphoserine/phospho-threonine phosphatase inhibitor increased the basal phosphorylation of RelA and reversed the inhibitory effect of 15d-PGJ(2) on LPS-induced RelA phosphorylation. | calyculin A | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 7 | Calyculin A, a specific phosphoserine/phospho-threonine phosphatase inhibitor increased the basal phosphorylation of RelA and reversed the inhibitory effect of 15d-PGJ(2) on LPS-induced RelA phosphorylation. | calyculin A | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 8 | We concluded that 15d-PGJ(2) may help to control NF-kappaB signaling and normal intestinal homeostasis to the enteric microflora by modulating RelA phosphorylation in IEC through altered protein phosphatase 2A activity. | 15d-pgj | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |