Title : Importance of the angiotensin type 1 receptor in angiotensin II-induced bronchoconstriction and bronchial hyperresponsiveness in the guinea pig.

Pub. Date : 2004 Apr-May

PMID : 15195554






2 Functional Relationships(s)
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1 Pretreatment with TCV-116, a type 1 Ang II (AT1) receptor antagonist, but not PD123319, a type 2 Ang II (AT2) receptor antagonist, dose dependently prevented both the Ang II-induced bronchoconstriction and bronchial hyperresponsiveness to methacholine. candesartan cilexetil type-1 angiotensin II receptor Cavia porcellus
2 The authors conclude that Ang II caused bronchoconstriction and induced bronchial hyperresponsiveness to methacholine via the AT1 receptors and that this effect did not involve the release of other bronchoactive mediators. Methacholine Chloride type-1 angiotensin II receptor Cavia porcellus