Title : 4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells.

Pub. Date : 1992 Sep 15

PMID : 1516044






2 Functional Relationships(s)
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1 Here, we show that 4-hydroxynonenal (HNE) concentrations close to the level found in normal cells (in the range of 1 and 3 microM) can specifically induce changes in the expression of c-myc and gamma-globin mRNA in K562 cells, without inducing any toxic effects or affecting cell viability. 4-hydroxy-2-nonenal hemoglobin subunit gamma 1 Homo sapiens
2 Here, we show that 4-hydroxynonenal (HNE) concentrations close to the level found in normal cells (in the range of 1 and 3 microM) can specifically induce changes in the expression of c-myc and gamma-globin mRNA in K562 cells, without inducing any toxic effects or affecting cell viability. 4-hydroxy-2-nonenal hemoglobin subunit gamma 1 Homo sapiens