Title : Functions of pancreatic beta cells and adipocytes in bombesin receptor subtype-3-deficient mice.

Pub. Date : 2004 Jun 4

PMID : 15144894






3 Functional Relationships(s)
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1 We previously reported that mice lacking bombesin receptor subtype-3 (BRS-3) exhibit mild late-onset obesity and glucose intolerance [Nature 390 (1997) 160]. Glucose bombesin-like receptor 3 Mus musculus
2 We previously reported that mice lacking bombesin receptor subtype-3 (BRS-3) exhibit mild late-onset obesity and glucose intolerance [Nature 390 (1997) 160]. Glucose bombesin-like receptor 3 Mus musculus
3 In contrast, adipose tissues exhibited a marked difference: the uptake of [(14)C]2-deoxy-D-glucose by adipocytes isolated from BRS-3-deficient mice was not stimulated by 10(-7)M insulin addition, and membrane fractionation analysis showed that GLUT4 was barely detected in the fraction of plasma membrane in BRS-3-deficient mice in the presence of 10(-7)M insulin. Deoxyglucose bombesin-like receptor 3 Mus musculus