Title : Interleukin-10 expression in lipopolysaccharide-activated microglia is mediated by extracellular ATP in an autocrine fashion.

Pub. Date : 2004 May 19

PMID : 15129165






6 Functional Relationships(s)
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1 LPS-activated microglia rapidly released a low concentration of ATP (10-20 nM) into the medium, and the nanomolar range of extracellular ATP, ADP, adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S), and adenosine 5"-O-(2-thiodiphosphate) (ADP-beta-S) induced IL-10 secretion from microglia in a dose-dependent manner. adenosine 5'-O-(2-thiodiphosphate) ATPase phospholipid transporting 8A2 Homo sapiens
2 LPS-activated microglia rapidly released a low concentration of ATP (10-20 nM) into the medium, and the nanomolar range of extracellular ATP, ADP, adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S), and adenosine 5"-O-(2-thiodiphosphate) (ADP-beta-S) induced IL-10 secretion from microglia in a dose-dependent manner. adenosine 5'-O-(2-thiodiphosphate) ATPase phospholipid transporting 8A2 Homo sapiens
3 LPS-activated microglia rapidly released a low concentration of ATP (10-20 nM) into the medium, and the nanomolar range of extracellular ATP, ADP, adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S), and adenosine 5"-O-(2-thiodiphosphate) (ADP-beta-S) induced IL-10 secretion from microglia in a dose-dependent manner. adenosine 5'-O-(2-thiodiphosphate) ATPase phospholipid transporting 8A2 Homo sapiens
4 LPS-activated microglia rapidly released a low concentration of ATP (10-20 nM) into the medium, and the nanomolar range of extracellular ATP, ADP, adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S), and adenosine 5"-O-(2-thiodiphosphate) (ADP-beta-S) induced IL-10 secretion from microglia in a dose-dependent manner. adenosine 5'-O-(2-thiodiphosphate) ATPase phospholipid transporting 8A2 Homo sapiens
5 LPS-activated microglia rapidly released a low concentration of ATP (10-20 nM) into the medium, and the nanomolar range of extracellular ATP, ADP, adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S), and adenosine 5"-O-(2-thiodiphosphate) (ADP-beta-S) induced IL-10 secretion from microglia in a dose-dependent manner. adenosine 5'-O-(2-thiodiphosphate) ATPase phospholipid transporting 8A2 Homo sapiens
6 LPS-activated microglia rapidly released a low concentration of ATP (10-20 nM) into the medium, and the nanomolar range of extracellular ATP, ADP, adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S), and adenosine 5"-O-(2-thiodiphosphate) (ADP-beta-S) induced IL-10 secretion from microglia in a dose-dependent manner. adenosine 5'-O-(2-thiodiphosphate) ATPase phospholipid transporting 8A2 Homo sapiens