Title : Increased expression of phospholipase D in the heart with experimental autoimmune myocarditis in Lewis rats.

Pub. Date : 2004 Feb

PMID : 15015836






4 Functional Relationships(s)
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1 Western blot analysis showed that the level of the PLD1 isoform was significantly increased in the hearts of rats with EAM on days 14, 17 and 21 postimmunization (pi) (P < 0.01; control vs EAM at 14 pi, 17 pi and 21 pi). molibresib phospholipase D1 Rattus norvegicus
2 Western blot analysis showed that the level of the PLD1 isoform was significantly increased in the hearts of rats with EAM on days 14, 17 and 21 postimmunization (pi) (P < 0.01; control vs EAM at 14 pi, 17 pi and 21 pi). molibresib phospholipase D1 Rattus norvegicus
3 Some PLD1-positive cells were also positive for proliferating cell nuclear antigen in some cardiomyocytes or terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling in some macrophages, suggesting that PLD1 positive cells have a capacity for proliferation or apoptosis depending on cell types in the target organ. deoxyuridine triphosphate phospholipase D1 Rattus norvegicus
4 Thus, it is postulated that increased expression of PLD1 in EAM may support an early inflammatory response in proliferating inflammatory cells, and its expression in cardiomyocytes may help them to survive by activation of survival factors in hearts with EAM. molibresib phospholipase D1 Rattus norvegicus