Pub. Date : 2004 Mar
PMID : 15003309
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Negative regulation of gamma-globin gene expression by cyclic AMP-dependent pathway in erythroid cells. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 2 | OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. | Hemin | hemoglobin subunit gamma 1 | Homo sapiens |
| 3 | OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. | Butyrates | hemoglobin subunit gamma 1 | Homo sapiens |
| 4 | OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. | Hydroxyurea | hemoglobin subunit gamma 1 | Homo sapiens |
| 5 | OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. | Cyclic GMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 6 | OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. | Cyclic GMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 7 | Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 8 | Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 9 | Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. | Colforsin | hemoglobin subunit gamma 1 | Homo sapiens |
| 10 | Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. | Colforsin | hemoglobin subunit gamma 1 | Homo sapiens |
| 11 | CONCLUSIONS: These results suggested that the cAMP-dependent pathway, which is independent of MAPK pathways, plays a negative role in gamma-globin gene expression in K562 cells. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 12 | cAMP and cGMP may have differential roles in the regulation of gamma-globin gene expression in erythroid cells. | Cyclic AMP | hemoglobin subunit gamma 1 | Homo sapiens |
| 13 | cAMP and cGMP may have differential roles in the regulation of gamma-globin gene expression in erythroid cells. | Cyclic GMP | hemoglobin subunit gamma 1 | Homo sapiens |