Title : Negative regulation of gamma-globin gene expression by cyclic AMP-dependent pathway in erythroid cells.

Pub. Date : 2004 Mar

PMID : 15003309






13 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Negative regulation of gamma-globin gene expression by cyclic AMP-dependent pathway in erythroid cells. Cyclic AMP hemoglobin subunit gamma 1 Homo sapiens
2 OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. Hemin hemoglobin subunit gamma 1 Homo sapiens
3 OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. Butyrates hemoglobin subunit gamma 1 Homo sapiens
4 OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. Hydroxyurea hemoglobin subunit gamma 1 Homo sapiens
5 OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. Cyclic GMP hemoglobin subunit gamma 1 Homo sapiens
6 OBJECTIVE: Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate gamma-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. Cyclic GMP hemoglobin subunit gamma 1 Homo sapiens
7 Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. Cyclic AMP hemoglobin subunit gamma 1 Homo sapiens
8 Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. Cyclic AMP hemoglobin subunit gamma 1 Homo sapiens
9 Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. Colforsin hemoglobin subunit gamma 1 Homo sapiens
10 Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of gamma-globin mRNA and decreased transcriptional activity of the gamma-globin gene promoter. Colforsin hemoglobin subunit gamma 1 Homo sapiens
11 CONCLUSIONS: These results suggested that the cAMP-dependent pathway, which is independent of MAPK pathways, plays a negative role in gamma-globin gene expression in K562 cells. Cyclic AMP hemoglobin subunit gamma 1 Homo sapiens
12 cAMP and cGMP may have differential roles in the regulation of gamma-globin gene expression in erythroid cells. Cyclic AMP hemoglobin subunit gamma 1 Homo sapiens
13 cAMP and cGMP may have differential roles in the regulation of gamma-globin gene expression in erythroid cells. Cyclic GMP hemoglobin subunit gamma 1 Homo sapiens