Title : Preparation and structure-activity relationships of simplified analogues of the antifungal agent cilofungin: a total synthesis approach.

Pub. Date : 1992 Jul 24

PMID : 1495015






1 Functional Relationships(s)
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1 The results suggests that the 3-hydroxy-4-methylproline residue enhances activity but the L-homotyrosine residue is crucial for both antifungal activity and the inhibition of beta-1,3-glucan synthesis. (S)-2-AMINO-4-(4-HYDROXYPHENYL)BUTANOIC ACID UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens