Title : Inhibitory effect of tellimagrandin I on chemically induced differentiation of human leukemia K562 cells.

Pub. Date : 2004 Mar 1

PMID : 14757314






1 Functional Relationships(s)
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1 RT-PCR analysis showed that tellimagrandin I decreased the expression of erythroid genes (gamma-globin and porphobilinogen deaminase (PBGD)) and related transcription factors (GATA-1 and NF-E2) in BA-induced K562 cells, whereas tellimagrandin I induced the overexpresison of GATA-2 transcription factor that played negative regulation on erythroid differentiation. tellimagrandin I hemoglobin subunit gamma 1 Homo sapiens