Title : Structural requirements for transformation of substrates by the S-adenosyl-L-methionine:delta 24(25)-sterol methyltransferase. Inhibition by analogs of the transition state coordinate.

Pub. Date : 1992 Dec 25

PMID : 1464600






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The hypothetical reaction course is described to proceed through an Sn2 formation of an activated complex involving the initial production of a covalent structure with a dative bond (methyl from AdoMet attacks si-face of the 24,25-double bond of the sterol) and the secondary production of a series of high energy intermediates, the stabilization of which determines the final C-24 methylated product. Sterols solute carrier family 38 member 5 Homo sapiens