Pub. Date : 2003 Dec
PMID : 14638499
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Molecular analysis of these mutants revealed single base pair exchanges in the ERG1 gene coding for squalene epoxidase, the target of terbinafine. | Terbinafine | squalene monooxygenase | Saccharomyces cerevisiae S288C |
| 2 | Terbinafine resistance was transmitted with the mutated alleles in gene replacement experiments, proving that single amino acid substitutions in the Erg1 protein were sufficient to confer the resistance phenotype. | Terbinafine | squalene monooxygenase | Saccharomyces cerevisiae S288C |
| 3 | Two mutations that were generated by PCR mutagenesis of the ERG1 gene and that conferred terbinafine resistance mapped in the same regions of the Erg1 protein, with one resulting in an L251F exchange and the other resulting in an F433S exchange. | Terbinafine | squalene monooxygenase | Saccharomyces cerevisiae S288C |
| 4 | Two mutations that were generated by PCR mutagenesis of the ERG1 gene and that conferred terbinafine resistance mapped in the same regions of the Erg1 protein, with one resulting in an L251F exchange and the other resulting in an F433S exchange. | Terbinafine | squalene monooxygenase | Saccharomyces cerevisiae S288C |