Title : Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites.

Pub. Date : 2004 Jan 23

PMID : 14594809






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration. Oxygen zinc finger and BTB domain containing 18 Homo sapiens