Pub. Date : 2004 Jan 2
PMID : 14532297
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously identified two cytochrome P450s, P450RAI-1 and P450RAI-2 (herein named CYP26A1 and CYP26B1), which were shown to be responsible for catabolism of atRA both in the embryo and the adult. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 2 | We have previously identified two cytochrome P450s, P450RAI-1 and P450RAI-2 (herein named CYP26A1 and CYP26B1), which were shown to be responsible for catabolism of atRA both in the embryo and the adult. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 3 | Specifically, CYP26C1 can also recognize and metabolize 9-cis-RA and is much less sensitive than the other CYP26 family members to the inhibitory effects of ketoconazole. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 4 | Specifically, CYP26C1 can also recognize and metabolize 9-cis-RA and is much less sensitive than the other CYP26 family members to the inhibitory effects of ketoconazole. | Ketoconazole | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 5 | This third CYP26 member may play a specific role in catabolizing both all-trans and 9-cis isomers of RA. | Radium | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |