Pub. Date : 2003 Oct 1
PMID : 14505347
5 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Catalase, but not MnSOD, inhibits glucose deprivation-activated ASK1-MEK-MAPK signal transduction pathway and prevents relocalization of Daxx: hydrogen peroxide as a major second messenger of metabolic oxidative stress. | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||
2 | Overexpression of catalase also inhibited relocalization of Daxx from the nucleus to the cytoplasm as well as association of Daxx with ASK1 during glucose deprivation. | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||
3 | Taken together, hydrogen peroxide (H(2)O(2)) rather than superoxide anion (O(2) (*-)) acts as a second messenger of metabolic oxidative stress to activate the ASK1-MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK)-mitogen-activated protein kinase (MAPK) signal transduction pathway. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||
4 | Taken together, hydrogen peroxide (H(2)O(2)) rather than superoxide anion (O(2) (*-)) acts as a second messenger of metabolic oxidative stress to activate the ASK1-MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK)-mitogen-activated protein kinase (MAPK) signal transduction pathway. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||
5 | Taken together, hydrogen peroxide (H(2)O(2)) rather than superoxide anion (O(2) (*-)) acts as a second messenger of metabolic oxidative stress to activate the ASK1-MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK)-mitogen-activated protein kinase (MAPK) signal transduction pathway. | Superoxides | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |