Pub. Date : 2003 Oct
PMID : 14500778
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Each amino acid in the extracellular region of the second transmembrane segment of the nAChR subunit alpha2 was mutated to cysteine. | Cysteine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 2 | Of the 11 mutants tested, 2 fulfilled criteria for participation in an alcohol binding site: alpha2(L262C)beta4 and alpha2(L263C)beta4. | Alcohols | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 3 | Of the 11 mutants tested, 2 fulfilled criteria for participation in an alcohol binding site: alpha2(L262C)beta4 and alpha2(L263C)beta4. | Alcohols | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 4 | Covalent binding of propanethiol to these cysteines did not change acetylcholine (ACh) affinity, but modified ACh maximal response in both cases: it increased for alpha2(L263C)beta4 and decreased for alpha2(L262C)beta4. | propanethiol | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 5 | Covalent binding of propanethiol to these cysteines did not change acetylcholine (ACh) affinity, but modified ACh maximal response in both cases: it increased for alpha2(L263C)beta4 and decreased for alpha2(L262C)beta4. | propanethiol | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 6 | Covalent binding of propanethiol to these cysteines did not change acetylcholine (ACh) affinity, but modified ACh maximal response in both cases: it increased for alpha2(L263C)beta4 and decreased for alpha2(L262C)beta4. | Cysteine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 7 | Covalent binding of propanethiol to these cysteines did not change acetylcholine (ACh) affinity, but modified ACh maximal response in both cases: it increased for alpha2(L263C)beta4 and decreased for alpha2(L262C)beta4. | Cysteine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 8 | Covalent binding of propanethiol to these cysteines did not change acetylcholine (ACh) affinity, but modified ACh maximal response in both cases: it increased for alpha2(L263C)beta4 and decreased for alpha2(L262C)beta4. | Acetylcholine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 9 | The same modifications on ACh responses were obtained with ethanol on alpha2(L263C)beta4 and octanol on alpha2(L262C)beta4. | Acetylcholine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 10 | The same modifications on ACh responses were obtained with ethanol on alpha2(L263C)beta4 and octanol on alpha2(L262C)beta4. | Acetylcholine | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 11 | The same modifications on ACh responses were obtained with ethanol on alpha2(L263C)beta4 and octanol on alpha2(L262C)beta4. | Ethanol | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |
| 12 | The same modifications on ACh responses were obtained with ethanol on alpha2(L263C)beta4 and octanol on alpha2(L262C)beta4. | Octanols | MGC75582, possible similarity to act2 S homeolog | Xenopus laevis |