Pub. Date : 1992 Nov 1
PMID : 1438222
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages. | Cholesterol | coagulation factor III, tissue factor | Homo sapiens |
| 2 | We investigated the effect of exogenous nonlipoprotein cholesterol on the expression of TF by human monocyte-derived macrophages in culture. | nonlipoprotein cholesterol | coagulation factor III, tissue factor | Homo sapiens |
| 3 | Nonlipoprotein cholesterol at 50 micrograms/ml increased TF activity 4-fold; TF induction was dose- and time-dependent. | nonlipoprotein cholesterol | coagulation factor III, tissue factor | Homo sapiens |
| 4 | Expression of TF activity was positively correlated with the free cholesterol content of monocyte-derived macrophages, was increased upon inhibition of cholesterol esterification, and reflected de novo synthesis of TF protein. | Cholesterol | coagulation factor III, tissue factor | Homo sapiens |
| 5 | Expression of TF activity was positively correlated with the free cholesterol content of monocyte-derived macrophages, was increased upon inhibition of cholesterol esterification, and reflected de novo synthesis of TF protein. | Cholesterol | coagulation factor III, tissue factor | Homo sapiens |
| 6 | TF expression in cholesterol-loaded macrophages remained sensitive to stimulation (approximately 12-fold) by bacterial lipopolysaccharide, indicating that intracellular free cholesterol and lipopolysaccharide act by distinct mechanisms in inducing TF procoagulant activity. | Cholesterol | coagulation factor III, tissue factor | Homo sapiens |
| 7 | TF expression in cholesterol-loaded macrophages remained sensitive to stimulation (approximately 12-fold) by bacterial lipopolysaccharide, indicating that intracellular free cholesterol and lipopolysaccharide act by distinct mechanisms in inducing TF procoagulant activity. | Cholesterol | coagulation factor III, tissue factor | Homo sapiens |
| 8 | TF expression in cholesterol-loaded macrophages remained sensitive to stimulation (approximately 12-fold) by bacterial lipopolysaccharide, indicating that intracellular free cholesterol and lipopolysaccharide act by distinct mechanisms in inducing TF procoagulant activity. | Cholesterol | coagulation factor III, tissue factor | Homo sapiens |
| 9 | TF expression in cholesterol-loaded macrophages remained sensitive to stimulation (approximately 12-fold) by bacterial lipopolysaccharide, indicating that intracellular free cholesterol and lipopolysaccharide act by distinct mechanisms in inducing TF procoagulant activity. | Cholesterol | coagulation factor III, tissue factor | Homo sapiens |
| 10 | Our results suggest that loading human monocyte-derived macrophages with free cholesterol induces upregulation of TF expression, thereby contributing to thrombus formation at sites of plaque rupture. | Cholesterol | coagulation factor III, tissue factor | Homo sapiens |