Title : Regulation of androgen receptor by androgen and epidermal growth factor in a human prostatic cancer cell line, LNCaP.

Pub. Date : 1992 Jun

PMID : 1425449






6 Functional Relationships(s)
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Protein Name
Organism
1 The addition of 1 nM dihydrotestosterone (DHT), at which the proliferation of the cells was most stimulated, did not change the level of AR mRNA but increased the level of AR protein by reducing the turnover rate of the AR protein. Dihydrotestosterone androgen receptor Homo sapiens
2 The addition of 1 nM dihydrotestosterone (DHT), at which the proliferation of the cells was most stimulated, did not change the level of AR mRNA but increased the level of AR protein by reducing the turnover rate of the AR protein. Dihydrotestosterone androgen receptor Homo sapiens
3 The addition of 1 nM dihydrotestosterone (DHT), at which the proliferation of the cells was most stimulated, did not change the level of AR mRNA but increased the level of AR protein by reducing the turnover rate of the AR protein. Dihydrotestosterone androgen receptor Homo sapiens
4 The addition of 1 nM dihydrotestosterone (DHT), at which the proliferation of the cells was most stimulated, did not change the level of AR mRNA but increased the level of AR protein by reducing the turnover rate of the AR protein. Dihydrotestosterone androgen receptor Homo sapiens
5 When DHT and EGF were added simultaneously to the cells, the level of AR mRNA was reduced to the same degree as was accomplished by the addition of EGF alone. Dihydrotestosterone androgen receptor Homo sapiens
6 On the other hand, the level of AR protein increased but this increase was about 70% of that attained following the addition of DHT alone. Dihydrotestosterone androgen receptor Homo sapiens