Pub. Date : 1992 Nov
PMID : 1423885
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to determine whether there was a correlation between the persistence of O6-methylguanine (O6-mGua) adducts and the rate of recovery of O6-methylguanine-DNA methyltransferase (O6-mGuaT) after depletion in the liver and susceptibility to NNK in F344 rat and Syrian golden hamster injected s.c. with NNK (80 mg/kg). | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 2 | The aim of this study was to determine whether there was a correlation between the persistence of O6-methylguanine (O6-mGua) adducts and the rate of recovery of O6-methylguanine-DNA methyltransferase (O6-mGuaT) after depletion in the liver and susceptibility to NNK in F344 rat and Syrian golden hamster injected s.c. with NNK (80 mg/kg). | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 3 | The aim of this study was to determine whether there was a correlation between the persistence of O6-methylguanine (O6-mGua) adducts and the rate of recovery of O6-methylguanine-DNA methyltransferase (O6-mGuaT) after depletion in the liver and susceptibility to NNK in F344 rat and Syrian golden hamster injected s.c. with NNK (80 mg/kg). | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 4 | The aim of this study was to determine whether there was a correlation between the persistence of O6-methylguanine (O6-mGua) adducts and the rate of recovery of O6-methylguanine-DNA methyltransferase (O6-mGuaT) after depletion in the liver and susceptibility to NNK in F344 rat and Syrian golden hamster injected s.c. with NNK (80 mg/kg). | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 5 | The aim of this study was to determine whether there was a correlation between the persistence of O6-methylguanine (O6-mGua) adducts and the rate of recovery of O6-methylguanine-DNA methyltransferase (O6-mGuaT) after depletion in the liver and susceptibility to NNK in F344 rat and Syrian golden hamster injected s.c. with NNK (80 mg/kg). | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 6 | The aim of this study was to determine whether there was a correlation between the persistence of O6-methylguanine (O6-mGua) adducts and the rate of recovery of O6-methylguanine-DNA methyltransferase (O6-mGuaT) after depletion in the liver and susceptibility to NNK in F344 rat and Syrian golden hamster injected s.c. with NNK (80 mg/kg). | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 7 | O6-mGua in NNK-treated rat liver was undetectable after 48 h. In the rat, the depletion of O6-mGuaT activity occurred within 4 h following NNK treatment. | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 8 | An aldehyde generated by alpha-hydroxylation of NNK, 4-oxo-4-(3-pyridyl)butanal, inhibited O6-mGuaT activity in rat hepatocytes, suggesting that this aldehyde contributes to the carcinogenicity of NNK by inhibiting this repair enzyme. | Aldehydes | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 9 | An aldehyde generated by alpha-hydroxylation of NNK, 4-oxo-4-(3-pyridyl)butanal, inhibited O6-mGuaT activity in rat hepatocytes, suggesting that this aldehyde contributes to the carcinogenicity of NNK by inhibiting this repair enzyme. | 4-oxo-4-(3-pyridinebutanal) | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 10 | An aldehyde generated by alpha-hydroxylation of NNK, 4-oxo-4-(3-pyridyl)butanal, inhibited O6-mGuaT activity in rat hepatocytes, suggesting that this aldehyde contributes to the carcinogenicity of NNK by inhibiting this repair enzyme. | Aldehydes | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |