Title : Stress factors affecting expression of O6-methylguanine-DNA methyltransferase mRNA in rat hepatoma cells.

Pub. Date : 1992 Nov 15

PMID : 1420362






3 Functional Relationships(s)
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Protein Name
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1 Treatments that damage DNA such as alkylation, hydrogen peroxide, ultraviolet or X-ray exposure, as well as restriction enzymes introduced into cells by electroporation or arrest of replication by hydroxyurea significantly induced MGMT mRNA (2.5 to 5-fold). Hydrogen Peroxide O-6-methylguanine-DNA methyltransferase Rattus norvegicus
2 On the other hand, an inhibitor of phosphatases (sodium vanadate) prevented induction of MGMT by N-methyl-N"-nitro-N-nitrosoguanidine. Vanadates O-6-methylguanine-DNA methyltransferase Rattus norvegicus
3 On the other hand, an inhibitor of phosphatases (sodium vanadate) prevented induction of MGMT by N-methyl-N"-nitro-N-nitrosoguanidine. Methylnitronitrosoguanidine O-6-methylguanine-DNA methyltransferase Rattus norvegicus