Pub. Date : 1992 Jul
PMID : 1386984
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ganglioside GM2 levels in human melanoma cells: inverse correlation with lysosomal beta-hexosaminidase A activity. | Gangliosides | hexosaminidase subunit alpha | Homo sapiens |
| 2 | Ganglioside GM2 levels in human melanoma cells: inverse correlation with lysosomal beta-hexosaminidase A activity. | gm2 | hexosaminidase subunit alpha | Homo sapiens |
| 3 | The lysosomal hydrolase beta-hexosaminidase A (Hex A), is an isoenzyme required for terminal GalNAc hydrolysis from intact GM2 to GM3. | N-acetylgalactosaminuronic acid | hexosaminidase subunit alpha | Homo sapiens |
| 4 | The lysosomal hydrolase beta-hexosaminidase A (Hex A), is an isoenzyme required for terminal GalNAc hydrolysis from intact GM2 to GM3. | N-acetylgalactosaminuronic acid | hexosaminidase subunit alpha | Homo sapiens |
| 5 | The lysosomal hydrolase beta-hexosaminidase A (Hex A), is an isoenzyme required for terminal GalNAc hydrolysis from intact GM2 to GM3. | gm2 | hexosaminidase subunit alpha | Homo sapiens |
| 6 | The lysosomal hydrolase beta-hexosaminidase A (Hex A), is an isoenzyme required for terminal GalNAc hydrolysis from intact GM2 to GM3. | gm2 | hexosaminidase subunit alpha | Homo sapiens |
| 7 | The lysosomal hydrolase beta-hexosaminidase A (Hex A), is an isoenzyme required for terminal GalNAc hydrolysis from intact GM2 to GM3. | gm3 | hexosaminidase subunit alpha | Homo sapiens |
| 8 | The lysosomal hydrolase beta-hexosaminidase A (Hex A), is an isoenzyme required for terminal GalNAc hydrolysis from intact GM2 to GM3. | gm3 | hexosaminidase subunit alpha | Homo sapiens |
| 9 | The objective of the present studies is to determine if the elevated levels of gangliosides, particularly GM2, correlate with the activity of Hex A in cultured melanoma cells. | Gangliosides | hexosaminidase subunit alpha | Homo sapiens |
| 10 | The objective of the present studies is to determine if the elevated levels of gangliosides, particularly GM2, correlate with the activity of Hex A in cultured melanoma cells. | gm2 | hexosaminidase subunit alpha | Homo sapiens |
| 11 | The Hex A activity in 13 melanoma cell lines ranged from 26%-88.3% There was a inverse correlation between GM2 nmole/g and Hex A activity (r = -0.48; p less than 0.003). | gm2 | hexosaminidase subunit alpha | Homo sapiens |
| 12 | The Hex A activity in 13 melanoma cell lines ranged from 26%-88.3% There was a inverse correlation between GM2 nmole/g and Hex A activity (r = -0.48; p less than 0.003). | gm2 | hexosaminidase subunit alpha | Homo sapiens |
| 13 | There was an inverse correlation (r = -0.53; p less than 0.05 and r = -0.51; p less than 0.05, respectively) between the ratio of substrate/product (GM2/GM3) and (GD2/GD3) and Hex A activity. | gm2 | hexosaminidase subunit alpha | Homo sapiens |
| 14 | These results indicate that the level of GM2 in melanoma is inversely correlated with the level of activity of Hex A. | gm2 | hexosaminidase subunit alpha | Homo sapiens |