Pub. Date : 1992 Aug
PMID : 1380082
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulation by risperidone of rat prolactin secretion in vivo and in cultured pituitary cells in vitro. | Risperidone | prolactin | Rattus norvegicus |
| 2 | Risperidone, a new antipsychotic agent which antagonizes both 5-hydroxytryptamine-2 (5-HT2) and dopamine-2 (D2) receptors, was evaluated for its effects on prolactin release. | Risperidone | prolactin | Rattus norvegicus |
| 3 | dosing, risperidone was 3 to 5 times more potent than the classical D2 receptor antagonist haloperidol in stimulating rat prolactin levels in vivo. | Risperidone | prolactin | Rattus norvegicus |
| 4 | Compared to haloperidol, risperidone was 0.34 (95% confidence interval: 0.23, 0.48) times as potent in reversing the suppression by dopamine of rat anterior pituitary cell prolactin release in vitro, which is consistent with the compounds" striatal D2 receptor binding potencies in vitro. | Risperidone | prolactin | Rattus norvegicus |
| 5 | Risperidone"s ability to increase prolactin release was unchanged after S-9 treatment, and 9-hydroxy-risperidone, identified as a major metabolite in the S-9 conditioned media, was equipotent to risperidone in modulating prolactin release in vitro. | Risperidone | prolactin | Rattus norvegicus |