Pub. Date : 1992 Jun 23
PMID : 1378737
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of TSase by FUra was modulated by leucovorin (LV), and the incorporation of FUra into RNA was increased by the administration of otherwise lethal doses of FUra followed by uridine "rescue". | Fluorouracil | thymidylate synthase | Mus musculus |
| 2 | Thymidylate synthase activity was inhibited substantially (49%) by low-dose FUra at 25 mg/kg, but was not further enhanced (48%) by repeated daily treatments at the same dose (FUra25 x 4). | Fluorouracil | thymidylate synthase | Mus musculus |
| 3 | FUra as a single agent at the maximum tolerated weekly dose of 100 mg/kg inhibited TSase activity 66-73%. | Fluorouracil | thymidylate synthase | Mus musculus |
| 4 | At a very-high-dose of FUra (200-225 mg/kg) followed by uridine "rescue", TSase inhibition was not further enhanced, but both (FU)RNA (4.8 nmol/mg DNA) and the therapeutic efficacy were increased. | Fluorouracil | thymidylate synthase | Mus musculus |