Title : Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia.

Pub. Date : 1992 May

PMID : 1374461






5 Functional Relationships(s)
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1 Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia. Capsaicin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 However, the inflammation-induced increases in Fos-like immunoreactivity (Fos-LI) and in PPD mRNA were greatly attenuated by neonatal capsaicin treatment. Capsaicin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 However, the inflammation-induced increases in Fos-like immunoreactivity (Fos-LI) and in PPD mRNA were greatly attenuated by neonatal capsaicin treatment. Capsaicin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
4 Our finding that neonatal capsaicin reduces the levels of Fos-LI and PPD mRNA in a related fashion in the spinal dorsal horn provides further evidence for a relationship between the protein product of the c-fos protooncogene and regulation of dynorphin gene transcription. Capsaicin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
5 Our finding that neonatal capsaicin reduces the levels of Fos-LI and PPD mRNA in a related fashion in the spinal dorsal horn provides further evidence for a relationship between the protein product of the c-fos protooncogene and regulation of dynorphin gene transcription. Capsaicin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens