Pub. Date : 1992 Apr
PMID : 1373797
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The NOS-II activities corresponded to a 130-kDa protein, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, which was not recognized in a protein immunoblot with anti-NOS-I antibody. | Sodium Dodecyl Sulfate | nitric oxide synthase 2, inducible | Mus musculus |
| 2 | The NOS-II activities corresponded to a 130-kDa protein, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, which was not recognized in a protein immunoblot with anti-NOS-I antibody. | polyacrylamide gels | nitric oxide synthase 2, inducible | Mus musculus |
| 3 | The serine protease inhibitor tosyl-lysyl chloromethyl ketone abolished the induction of NOS-II by INF/LPS, by depleting intracellular thiol pools and interfering with protein synthesis. | tosyl lysyl chloromethyl ketone | nitric oxide synthase 2, inducible | Mus musculus |
| 4 | The serine protease inhibitor tosyl-lysyl chloromethyl ketone abolished the induction of NOS-II by INF/LPS, by depleting intracellular thiol pools and interfering with protein synthesis. | Sulfhydryl Compounds | nitric oxide synthase 2, inducible | Mus musculus |
| 5 | Induction of NOS-II by INF/LPS was transcriptionally based and, for maximal enzyme activity, required increased intracellular tetrahydrobiopterin levels, intracellular Ca2+ mobilization, and activation of non-L-type Ca2+ channels but, unlike the induction of macrophage-mediated cytotoxicity, neither L-type-Ca2+ channels nor calmodulin. | sapropterin | nitric oxide synthase 2, inducible | Mus musculus |