Title : Identification of a heparin-binding growth factor-1 nuclear translocation sequence by deletion mutation analysis.

Pub. Date : 1992 Mar 15

PMID : 1372009






1 Functional Relationships(s)
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1 We have shown previously that a deletion mutant of human heparin-binding growth factor (HBGF)-1, HBGF-1U, lacking the sequence Asn-Tyr-Lys-Lys-Pro-Lys-Leu is capable of initiating c-fos mRNA expression and polypeptide phosphorylation on tyrosine residues at concentrations that do not induce either DNA synthesis or cell proliferation (1). Pro-Lys-Leu Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens