Title : D1 and D2 dopamine receptors differentially regulate c-fos expression in striatonigral and striatopallidal neurons.

Pub. Date : 1992 Jul

PMID : 1359451






9 Functional Relationships(s)
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1 D1, but not D2, dopamine receptor agonists have previously been shown to increase Fos immunoreactivity in striatonigral neurons ipsilateral to a 6-hydroxydopamine lesion of the nigrostriatal pathway. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 In the present study, it was demonstrated that the D1 receptor agonist SKF 38393 rarely increased Fos in striatopallidal neurons of the 6-hydroxydopamine denervated striatum. 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 In the present study, it was demonstrated that the D1 receptor agonist SKF 38393 rarely increased Fos in striatopallidal neurons of the 6-hydroxydopamine denervated striatum. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
4 Conversely, in the intact striatum, the D2 receptor antagonist haloperidol enhanced Fos expression predominantly in striatopallidal neurons labelled retrogradely from the globus pallidus or with an oligonucleotide probe complementary to mRNA encoding enkephalin. Haloperidol Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
5 Conversely, in the intact striatum, the D2 receptor antagonist haloperidol enhanced Fos expression predominantly in striatopallidal neurons labelled retrogradely from the globus pallidus or with an oligonucleotide probe complementary to mRNA encoding enkephalin. Oligonucleotides Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
6 In another experiment the selective D2 receptor agonist quinpirole was found to increase Fos immunoreactivity in the globus pallidus ipsilateral to a 6-hydroxydopamine lesion. Quinpirole Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
7 In another experiment the selective D2 receptor agonist quinpirole was found to increase Fos immunoreactivity in the globus pallidus ipsilateral to a 6-hydroxydopamine lesion. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
8 Local application of the selective D1 receptor agonist CY 208-243 in the 6-hydroxydopamine-denervated striatum, or of haloperidol in the intact striatum via the dialysis probe increased Fos immunoreactivity in the immediate vicinity of the probe. Cysteine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
9 Local application of the selective D1 receptor agonist CY 208-243 in the 6-hydroxydopamine-denervated striatum, or of haloperidol in the intact striatum via the dialysis probe increased Fos immunoreactivity in the immediate vicinity of the probe. Haloperidol Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens