Title : Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages.

Pub. Date : 1992 Jul

PMID : 1353517






3 Functional Relationships(s)
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1 Induction of TNF mRNA by 10 microM taxol was detectable at 45 min of stimulation, maximal at 90 min, and evident for at least 8 h. The same low concentration of taxol also induced interleukin 1 (IL-1) alpha and beta mRNA expression. Paclitaxel interleukin 1 complex Mus musculus
2 Induction of TNF mRNA by 10 microM taxol was detectable at 45 min of stimulation, maximal at 90 min, and evident for at least 8 h. The same low concentration of taxol also induced interleukin 1 (IL-1) alpha and beta mRNA expression. Paclitaxel interleukin 1 complex Mus musculus
3 We conclude that taxol triggers macrophages for TNF and IL-1 production. Paclitaxel interleukin 1 complex Mus musculus