Pub. Date : 1992
PMID : 1347406
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, a single injection of the typical antipsychotic haloperidol has been shown to increase c-fos expression in the striatum [Dragunow et al. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | The present experiments examined some potential neuroanatomical differences in the actions of clozapine and haloperidol by comparing their effects on c-fos expression in the medial prefrontal cortex, nucleus accumbens, striatum and lateral septum. | Clozapine | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | The present experiments examined some potential neuroanatomical differences in the actions of clozapine and haloperidol by comparing their effects on c-fos expression in the medial prefrontal cortex, nucleus accumbens, striatum and lateral septum. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | Haloperidol (0.5, 1 mg/kg) and raclopride (1, 2 mg/kg) produced large increases in the number of Fos-containing neurons in the striatum and nucleus accumbens. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 5 | Haloperidol (0.5, 1 mg/kg) and raclopride (1, 2 mg/kg) produced large increases in the number of Fos-containing neurons in the striatum and nucleus accumbens. | Raclopride | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 6 | Haloperidol, but not raclopride, produced a modest increase in c-fos expression in the lateral septal nucleus. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 7 | Clozapine (10, 20 mg/kg) was without effect in the striatum; however, it significantly increased the number of Fos-positive neurons in the nucleus accumbens, medial prefrontal cortex and lateral septal nucleus. | Clozapine | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 8 | Destruction of mesotelencephalic dopaminergic neurons with 6-hydroxydopamine abolished the increase in Fos expression in the nucleus accumbens and striatum produced by haloperidol and raclopride, and also blocked the clozapine-induced increase in the nucleus accumbens. | Oxidopamine | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 9 | Destruction of mesotelencephalic dopaminergic neurons with 6-hydroxydopamine abolished the increase in Fos expression in the nucleus accumbens and striatum produced by haloperidol and raclopride, and also blocked the clozapine-induced increase in the nucleus accumbens. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 10 | Destruction of mesotelencephalic dopaminergic neurons with 6-hydroxydopamine abolished the increase in Fos expression in the nucleus accumbens and striatum produced by haloperidol and raclopride, and also blocked the clozapine-induced increase in the nucleus accumbens. | Raclopride | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 11 | Destruction of mesotelencephalic dopaminergic neurons with 6-hydroxydopamine abolished the increase in Fos expression in the nucleus accumbens and striatum produced by haloperidol and raclopride, and also blocked the clozapine-induced increase in the nucleus accumbens. | Clozapine | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 12 | However, the inductive effects of clozapine and haloperidol on c-fos expression in the lateral septal nucleus and of clozapine in the medial prefrontal cortex were not affected by the 6-hydroxydopamine lesions. | Clozapine | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 13 | However, the inductive effects of clozapine and haloperidol on c-fos expression in the lateral septal nucleus and of clozapine in the medial prefrontal cortex were not affected by the 6-hydroxydopamine lesions. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |