Pub. Date : 1992 Nov
PMID : 1336517
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To test the hypothesis that enhanced expression of the vasopressin gene accompanies the development of deoxycorticosterone acetate (DOCA)-salt hypertension in the rat and to compare the response with those observed during chronic hypernatremia. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 2 | OBJECTIVE: To test the hypothesis that enhanced expression of the vasopressin gene accompanies the development of deoxycorticosterone acetate (DOCA)-salt hypertension in the rat and to compare the response with those observed during chronic hypernatremia. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 3 | RESULTS: Vasopressin mRNA levels were increased in the paraventricular nucleus during the established and chronic stages of DOCA-salt hypertension, but were unchanged in the supraoptic nucleus. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 4 | Urinary excretion of vasopressin was increased in the prehypertensive, established and chronic phases of DOCA-salt hypertension, whereas plasma vasopressin levels were increased only in the chronic phase. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 5 | CONCLUSION: Whereas hypernatremic rats showed markedly elevated vasopressin transcripts in the supraoptic and paraventricular nuclei, DOCA-salt hypertension is associated with increased vasopressin mRNA in the paraventricular but not the supraoptic nucleus. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 6 | The response in the paraventricular nucleus may explain part of the increased peripheral vasopressin levels and suggests that this nucleus makes a critical contribution to the pathogenesis of DOCA-salt hypertension. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |