Title : Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation.

Pub. Date : 1992 Oct

PMID : 1328861






2 Functional Relationships(s)
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1 To determine whether the increases in c-fos and c-jun mRNA induced by carbachol and thrombin are sufficient to stimulate AP-1-mediated transactivation, 1321N1 cells were transfected with a reporter carrying two copies of the tetradecanoyl phorbol acetate response element and the firefly luciferase gene. Carbachol Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Carbachol and thrombin have similar effects on expression of c-fos, fosB, fra-2, junB, and junD, both acutely and over a 24-h time course. Carbachol Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens