Title : Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes.

Pub. Date : 1992 Aug

PMID : 1321333






6 Functional Relationships(s)
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1 Microinjection of either Ki-rasVal-12 p21 or the GDP-bound form of Ki-ras p21 plus smg GDP dissociation stimulator (GDS), a stimulatory GDP/GTP exchange protein for Ki-ras p21, smg/rap1/Krev-1 p21, and rho p21, into quiescent Swiss 3T3 cells induced DNA synthesis irrespective of the presence or absence of insulin. Guanosine Diphosphate cyclin-dependent kinase inhibitor 1A (P21) Mus musculus
2 Microinjection of either Ki-rasVal-12 p21 or the GDP-bound form of Ki-ras p21 plus smg GDP dissociation stimulator (GDS), a stimulatory GDP/GTP exchange protein for Ki-ras p21, smg/rap1/Krev-1 p21, and rho p21, into quiescent Swiss 3T3 cells induced DNA synthesis irrespective of the presence or absence of insulin. Guanosine Diphosphate cyclin-dependent kinase inhibitor 1A (P21) Mus musculus
3 Microinjection of either Ki-rasVal-12 p21 or the GDP-bound form of Ki-ras p21 plus smg GDP dissociation stimulator (GDS), a stimulatory GDP/GTP exchange protein for Ki-ras p21, smg/rap1/Krev-1 p21, and rho p21, into quiescent Swiss 3T3 cells induced DNA synthesis irrespective of the presence or absence of insulin. Guanosine Diphosphate cyclin-dependent kinase inhibitor 1A (P21) Mus musculus
4 Microinjection of either Ki-rasVal-12 p21 or the GDP-bound form of Ki-ras p21 plus smg GDP dissociation stimulator (GDS), a stimulatory GDP/GTP exchange protein for Ki-ras p21, smg/rap1/Krev-1 p21, and rho p21, into quiescent Swiss 3T3 cells induced DNA synthesis irrespective of the presence or absence of insulin. Guanosine Diphosphate cyclin-dependent kinase inhibitor 1A (P21) Mus musculus
5 Either the GDP-bound form of Ki-ras p21 or the same form of smg p21B alone was inactive, but smg GDS alone was slightly active only in the presence of insulin. Guanosine Diphosphate cyclin-dependent kinase inhibitor 1A (P21) Mus musculus
6 Either the GDP-bound form of Ki-ras p21, the same form of smg p21B, or smg GDS alone was inactive. Guanosine Diphosphate cyclin-dependent kinase inhibitor 1A (P21) Mus musculus