Pub. Date : 1992 Apr
PMID : 1313393
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | C-type natriuretic peptide inhibits thrombin- and angiotensin II-stimulated endothelin release via cyclic guanosine 3",5"-monophosphate. | Cyclic GMP | natriuretic peptide C | Homo sapiens |
| 2 | In addition, CNP potently increased the cellular level of cyclic guanosine 3",5"-monophosphate (GMP), with the inhibition of immunoreactive endothelin-1 secretion in response to thrombin and Ang II being paralleled by the increase in the cyclic GMP level. | Cyclic GMP | natriuretic peptide C | Homo sapiens |
| 3 | In addition, CNP potently increased the cellular level of cyclic guanosine 3",5"-monophosphate (GMP), with the inhibition of immunoreactive endothelin-1 secretion in response to thrombin and Ang II being paralleled by the increase in the cyclic GMP level. | Cyclic GMP | natriuretic peptide C | Homo sapiens |
| 4 | In addition, CNP potently increased the cellular level of cyclic guanosine 3",5"-monophosphate (GMP), with the inhibition of immunoreactive endothelin-1 secretion in response to thrombin and Ang II being paralleled by the increase in the cyclic GMP level. | Cyclic GMP | natriuretic peptide C | Homo sapiens |
| 5 | The increase of cyclic GMP produced by CNP was also greater than that due to porcine ANP(1-28) or porcine BNP-26. | Cyclic GMP | natriuretic peptide C | Homo sapiens |
| 6 | Our results suggest that CNP probably inhibits the endothelin-1 secretion stimulated by thrombin and Ang II through a cyclic GMP-dependent process. | Cyclic GMP | natriuretic peptide C | Homo sapiens |
| 7 | The increase of cyclic GMP levels and the inhibition of immunoreactive endothelin-1 secretion produced by CNP appear to be greater than those produced by ANP or BNP. | Cyclic GMP | natriuretic peptide C | Homo sapiens |