Title : Increased phosphorylation of nuclear phosphoproteins in human lung-cancer cells resistant to cis-diamminedichloroplatinum (II).

Pub. Date : 1992 Feb 1

PMID : 1310490






4 Functional Relationships(s)
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1 We previously showed that cis-diamminedichloroplatinum(II) (CDDP)-resistant cells, PC-9/CDDP, were cross-resistant to OA and that the cross-resistance was not due to the increased efflux of OA. Cisplatin proprotein convertase subtilisin/kexin type 9 Homo sapiens
2 We previously showed that cis-diamminedichloroplatinum(II) (CDDP)-resistant cells, PC-9/CDDP, were cross-resistant to OA and that the cross-resistance was not due to the increased efflux of OA. Cisplatin proprotein convertase subtilisin/kexin type 9 Homo sapiens
3 By SDS-PAGE after incubation of intact cells with 32P, we detected a marked increase, compared to PC-9 cells, in phosphorylation of the nuclear proteins of MW 32 and 20 kDa in CDDP-resistant PC-9/CDDP cells with no apparent difference in protein content. Cisplatin proprotein convertase subtilisin/kexin type 9 Homo sapiens
4 By SDS-PAGE after incubation of intact cells with 32P, we detected a marked increase, compared to PC-9 cells, in phosphorylation of the nuclear proteins of MW 32 and 20 kDa in CDDP-resistant PC-9/CDDP cells with no apparent difference in protein content. Cisplatin proprotein convertase subtilisin/kexin type 9 Homo sapiens