Title : The hemicholinium-3 sensitive high affinity choline transporter is internalized by clathrin-mediated endocytosis and is present in endosomes and synaptic vesicles.

Pub. Date : 2003 Oct

PMID : 12969261






5 Functional Relationships(s)
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1 Synthesis of acetylcholine depends on the plasma membrane uptake of choline by a high affinity choline transporter (CHT1). Acetylcholine solute carrier family 5 member 7 Homo sapiens
2 Synthesis of acetylcholine depends on the plasma membrane uptake of choline by a high affinity choline transporter (CHT1). Choline solute carrier family 5 member 7 Homo sapiens
3 Choline uptake is regulated by nerve impulses and trafficking of an intracellular pool of CHT1 to the plasma membrane may be important for this regulation. Choline solute carrier family 5 member 7 Homo sapiens
4 Expression of CHT1-HA in HEK 293 cells establishes Na+-dependent, hemicholinium-3 sensitive high-affinity choline transport activity. Choline solute carrier family 5 member 7 Homo sapiens
5 We propose that intracellular CHT1 can be recruited during stimulation to increase choline uptake in nerve terminals. Choline solute carrier family 5 member 7 Homo sapiens