Title : Ras is a mediator of TGFbeta1 signaling in developing chick ciliary ganglion neurons.

Pub. Date : 2003 Aug 22

PMID : 12915246






4 Functional Relationships(s)
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1 Here we show that TGFbeta1 stimulation of K(Ca) expression was blocked by the structurally dissimilar Ras protein farnesyl transferase inhibitors manumycin-A and FTI-277. manumycin transforming growth factor beta 1 Gallus gallus
2 Here we show that TGFbeta1 stimulation of K(Ca) expression was blocked by the structurally dissimilar Ras protein farnesyl transferase inhibitors manumycin-A and FTI-277. FTI 277 transforming growth factor beta 1 Gallus gallus
3 Moreover, TGFbeta1-evoked increases in phosphorylation of SMAD2 were reduced by manumycin-A, suggesting that Ras-dependent transduction cascades activated by TGFbeta1 feed back onto SMAD signaling. manumycin transforming growth factor beta 1 Gallus gallus
4 Moreover, TGFbeta1-evoked increases in phosphorylation of SMAD2 were reduced by manumycin-A, suggesting that Ras-dependent transduction cascades activated by TGFbeta1 feed back onto SMAD signaling. manumycin transforming growth factor beta 1 Gallus gallus