Pub. Date : 2003 Nov
PMID : 12883077
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 2 | In order to use the zebrafish as a model vertebrate to investigate the developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), it is essential to know whether one or both forms of the zebrafish aryl hydrocarbon receptor (AHR), zfAHR1 or zfAHR2, mediate toxicity. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 3 | Injection of embryos at the 1-2 cell stage with zfahr2-MO decreased TCDD-induced transcription of zfCYP1A mRNA until 96 h post fertilization (hpf), and immuno-histochemical detection of zfCYP1A protein in embryos at 72 hpf revealed a dramatic decrease in expression. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 4 | The zfahr2-MO completely protected embryos from TCDD-induced edema and anemia and provided protection against TCDD-induced reductions in peripheral blood flow initially; however, a slight reduction in blood flow was observed at later times when the morpholino was no longer effective. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 5 | The zfahr2-MO completely protected embryos from TCDD-induced edema and anemia and provided protection against TCDD-induced reductions in peripheral blood flow initially; however, a slight reduction in blood flow was observed at later times when the morpholino was no longer effective. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 6 | Endpoints of TCDD developmental toxicity manifested in zfahr2 morphants at late stages of development, beyond 144 hpf, were clearly different from TCDD-exposed embryos injected with a control morpholino. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |
| 7 | Most strikingly, zfahr2 morphants exposed to TCDD never developed edema. | Polychlorinated Dibenzodioxins | aryl hydrocarbon receptor 2 | Danio rerio |