Pub. Date : 2003 Oct 3
PMID : 12876291
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in the oxygen-dependent degradation domain (ODD) of hypoxia-inducible factor-1alpha (HIF-1alpha). | Proline | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 2 | Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in the oxygen-dependent degradation domain (ODD) of hypoxia-inducible factor-1alpha (HIF-1alpha). | Oxygen | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 3 | We developed assays for PHD activity that used (i) the peptide-specific conversion of labeled 2-oxoglutarate into succinate and (ii) the binding of the von Hippel-Lindau protein to a glutathione S-transferase-ODD fusion protein. | Ketoglutaric Acids | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |
| 4 | We developed assays for PHD activity that used (i) the peptide-specific conversion of labeled 2-oxoglutarate into succinate and (ii) the binding of the von Hippel-Lindau protein to a glutathione S-transferase-ODD fusion protein. | Succinic Acid | egl-9 family hypoxia-inducible factor 1 | Rattus norvegicus |