Title : Effect of glucose concentration on activation of the ASK1-SEK1-JNK1 signal transduction pathway.

Pub. Date : 2003 Jul 1

PMID : 12858332






6 Functional Relationships(s)
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1 Effect of glucose concentration on activation of the ASK1-SEK1-JNK1 signal transduction pathway. Glucose mitogen-activated protein kinase kinase kinase 5 Homo sapiens
2 In this study, we investigated whether clinically relevant concentrations (0.01-0.1 mM) of glucose promote ASK1 activation. Glucose mitogen-activated protein kinase kinase kinase 5 Homo sapiens
3 Similar to JNK1 activation, we also observed that low glucose-induced ASK1 activation, dissociation of GRX and thioredoxin (TRX) from ASK1, dimerization of ASK1, and association of Daxx and TRAF2 with ASK1 significantly occurred at a glucose concentration less than or equal to 0.01 mM. Glucose mitogen-activated protein kinase kinase kinase 5 Homo sapiens
4 Similar to JNK1 activation, we also observed that low glucose-induced ASK1 activation, dissociation of GRX and thioredoxin (TRX) from ASK1, dimerization of ASK1, and association of Daxx and TRAF2 with ASK1 significantly occurred at a glucose concentration less than or equal to 0.01 mM. Glucose mitogen-activated protein kinase kinase kinase 5 Homo sapiens
5 Similar to JNK1 activation, we also observed that low glucose-induced ASK1 activation, dissociation of GRX and thioredoxin (TRX) from ASK1, dimerization of ASK1, and association of Daxx and TRAF2 with ASK1 significantly occurred at a glucose concentration less than or equal to 0.01 mM. Glucose mitogen-activated protein kinase kinase kinase 5 Homo sapiens
6 Similar to JNK1 activation, we also observed that low glucose-induced ASK1 activation, dissociation of GRX and thioredoxin (TRX) from ASK1, dimerization of ASK1, and association of Daxx and TRAF2 with ASK1 significantly occurred at a glucose concentration less than or equal to 0.01 mM. Glucose mitogen-activated protein kinase kinase kinase 5 Homo sapiens