Title : Local potentiation of bradykinin-induced vasodilation by converting-enzyme inhibition in isolated coronary arteries.

Pub. Date : 1992

PMID : 1282632






3 Functional Relationships(s)
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1 Lisinopril and captopril alone did not affect vascular tone; however, in rings with endothelium partially relaxed with bradykinin (> or = 10(-10) M), all ACE inhibitors caused further relaxations. Lisinopril angiotensin I converting enzyme Homo sapiens
2 Mechanical removal of the endothelium or incubation with nitro-L-arginine or the bradykinin2-receptor antagonist Hoe 140 prevented the relaxations to bradykinin and lisinopril. Lisinopril kininogen 1 Homo sapiens
3 Endothelium-dependent relaxations to lisinopril were also observed in human coronary arteries treated with bradykinin (> or = 10(-7) M). Lisinopril kininogen 1 Homo sapiens