Title : Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer.

Pub. Date : 2003 May 19

PMID : 12771922






3 Functional Relationships(s)
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1 CpG island methylation status of the cyclin D2 gene was studied by methylation-specific polymerase chain reaction and bisulphite sequencing. hydrogen sulfite cyclin D2 Homo sapiens
2 Bisulphite DNA sequencing revealed that loss of cyclin D2 expression was closely associated with the density of methylation in the promoter region. hydrogen sulfite cyclin D2 Homo sapiens
3 Treatment with DNA methyltransferase inhibitor, 5-aza-2"-deoxycytidine, restored the cyclin D2 expression level in methylated gastric cells. Decitabine cyclin D2 Homo sapiens