Title : Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1.

Pub. Date : 2003 Jun 6

PMID : 12763047






1 Functional Relationships(s)
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1 Inhibition of COX-2 activity with NS-398 abolished the stimulating effect of PFF both at 1 h and at 24 h post-incubation, while inhibition of COX-1 by SC-560 affected neither the early nor the late response to flow. SC 560 mitochondrially encoded cytochrome c oxidase I Homo sapiens